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Study thought of material basis of secondary development of major
traditional Chinese medicine varieties on basis of combination
of in vivo and in vitro experiments
CHENG Xu-dong1， 2， 3， JIA Xiao-bin1*， FENG Liang1， JIANG Jun1，2
（1.Key Laboratory of New Drug Delivery System of Chinese Materia Medica under State Administration of
Traditional Chinese Medicine， Jiangsu Provincial Academy of Chinese Medicine， Nanjing ， China；
2. Nanjing University of Chinese Medicine， Nanjing ， China；
3. Suzhou ALG Bioscience Co， Ltd.， Suzhou ， China）
[Abstract] The secondary development of major traditional Chinese medicine varieties is one of important links during the modernization， scientification and standardization of traditional Chinese medicines. How to accurately and effectively identify the pharmacodynamic material basis of original formulae becomes the primary problem in the secondary development， as well as the bottleneck in the modernization development of traditional Chinese medicines. On the basis of the existing experimental methods， and according to the study thought that the multi-component and complex effects of traditional Chinese medicine components need to combine multi-disciplinary methods and technologies， we propose the study thought of the material basis of secondary development of major traditional Chinese medicine varieties based on the combination of in vivo and in vitro experiments. It is believed that studies on material basis needs three links， namely identification， screening and verification， and in vivo and in vitro study method corresponding to each link is mutually complemented and verified. Finally， the accurate and reliable material basis is selected. This thought provides reference for the secondary development of major traditional Chinese medicine varieties and studies on compound material basis.
[Key words] traditional Chinese medicine； secondary development； combination of in vivo and in vitro experiments； study thought
doi：10.4268/cjcmm