NGAL、KIM—1和IL—18三者聯合檢測在兒童急性腎損傷早期診斷中的意義
臨床研究
作者：潘國權等
[摘要] 目的 探討NGAL、KIM-1和IL-18三者聯合檢測在兒童急性腎損傷（acute kidney injury，AKI）早期診斷中的意義。 方法 選取2011年6月～2013年6月在我院PICU的100例危重症患兒為研究對象，分為AKI組（40例）與非AKI組（n=60）。收集兩組患兒晨起尿液 6～8 mL，用酶聯免疫吸附法檢測尿液中 NGAL、IL-18和 KIM-1 水平，並將三個指標與血清肌酐進行比較，同時繪製ROC曲線，評價尿 NGAL、IL-18 和 KIM-1 在 AKI 早期診斷中價值。 結果 AKI組與非AKI組在年齡、性別、收縮壓、舒張壓、尿比重上無明顯差異（P>0.05）；AKI組與非AKI組比較，Scr、NGAL、KIM-1以及IL-18水平，均顯著提高，差異有統計學意義（P
[關鍵詞] 急性腎損傷；兒童；中性粒細胞明膠酶相關脂質運載蛋白；腎損傷分子 1
[中圖分類號] R726.9 [文獻標識碼] B [文章編號] 1673-9701（2015）09-0067-03
NGAL， KIM-1 and IL-18 three injury early diagnostic value in children with acute kidney
FAN Guoquan1 LIANG Yafeng1 LIN Beibei1 TANG Zhenhai1 CHEN Xu1 WANG Linxia1 CHEN Minguang2
1.Department of Pediatric Intensive Care Unit， the Second Affiliated Hospital & Yuying Children’s Hospital， Wenzhou Medical University，Wenzhou 325000，China；2.Department of Pediatric Nephrology， the Second Affiliated Hospital & Yuying Children’s Hospital， Wenzhou Medical University，Wenzhou 325000，China
[Abstract] Objective To discuss the significance of combined detection of NGAL， KIM-1 and IL-18 three in children with acute kidney injury in the diagnosis of early research. Methods From June 2011 to June 2013 in our hospital，100 cases of critically ill children with PICU as the research object， and were divided into group AKI（40 cases） and non AKI group（60 cases）. The collection of two groups of children with early morning urine 6-8 ml by enzyme linked immunosorbent assay（enzyme-linked immunosorbent， assay， ELISA） NGAL detection in urine， IL-18 and KIM-1 levels， and the three indexes and serum creatinine （serum creatinine， Scr） compared， at the same time to draw the ROC curve， evaluation of urinary NGAL， IL-18 and KIM-1 in the AKI value early diagnosis. Results The patients in the AKI group and non AKI group patients in age and sex， systolic blood pressure， diastolic blood pressure， urine specific gravity without obvious difference， and the difference had no statistical significance （P>0.05）； comparison of patients in the AKI group and non AKI group patients， Scr， NGAL， KIM-1 and IL-18 levels were significantly increased， the difference was statistical significant（P
[Key words] Acute renal injury； Children； Neutrophil gelatinase associated lipocalin； Hidney injury molecule 1