[Abstract] Objective： To investigate the effects of sapindus saponins on myocardial inflammation mediated by Ang Ⅱ/p38MAPK signal pathway and cardiac hypertrophy in spontaneously hypertensive rats . And also to explore the correlation of cardiac hypertrophy and inflammation. Method： Thirty，two 16，week，old spontaneously hypertensive rats （SHR） were randomly divided into four groups， one with placebo as model group， one with captopril tablets（27 mg·kg-1）as positive control， one with low，dose sapindus saponins（27 mg·kg-1）， one with high，dose （108 mg·kg-1）. And another eight healthy Wistar，Kyoto strain（WKY） rats were used as the normal group. The animals were treated for eight weeks， and the indicators detected were as follows： ①left ventricular mass index （LVMI）； ②the content of AngⅡ and hs，CRP in plasma were determined by ELISA；③the protein expression of AT1R and VEGF were determined by immunohistochemical method； ④the protein expression of p，p38MAPK in myocardial cells was determined by Western blot. Result： Sapindus saponins reduced LVMI， and blocked the expression level of AngⅡ， AT1R， p，p38MAPK， VEGF and hs，CRP in myocardial tissue. Vs the SHR model group， there were significant differences （P
[Key words] sapindus saponins； spontaneously hypertension； inflammatory response； cardiac hypertrophy