4.2.2苓桂術甘湯 通過在AD細胞模型上的應用[29],發現苓桂術甘湯可提高澱粉樣β蛋白25~35損傷的人神經母細胞瘤細胞SH-SY5Y的活力,同時可抑製活化的小膠質細胞BV-2培養液上清中白細胞介素1β、白細胞介素6、腫瘤壞死因子α及一氧化氮的含量來治療AD。
AD在中醫學中原無此名,但早在漢代華佗神醫秘傳《華佗治癡呆神方》中就有對癡呆的記載,因此中醫對AD的治療已有長久的曆史。但過去中醫治療常常偏重個人經驗,並無科學實驗支持,導致了所謂的隻有實用性、沒有“科學性”,因此,現在大量實驗通過先進的實驗手段將中藥的科學性加以證明,必將使中藥在治療AD的道路上越走越遠,並且走向世界,被全世界所接受
5小結
綜上所述,從短期講,藥物治療AD的現狀並不樂觀,針對發病機製研究的新藥紛紛受挫,短時間內尚不能研製出真正治愈AD的新藥。而目前現有專門用來治療AD的西藥雖然能在一定程度上改善AD的症狀,延緩AD的進展,但同時也存在著一定的副作用,而且大多靶點單一,費用昂貴,社會經濟負擔大;另外一些常規用於非治療AD的藥物雖然目前有研究表明對AD有療效,但尚缺乏大規模循證證據支持,故尚不能看作常規治療AD藥物。而中藥雖然較西藥有多靶點、注重個體、標本兼治等優點,但基礎研究和藥物的係統評價尚不夠完善,缺乏足夠多有效的數據作支撐,因此西藥間聯合應用或與中藥聯用可能會對AD的治療更有療效。從長遠看,目前世界各國投入了大量的人力物力研究AD新藥,雖然目前尚未成功,但隨著研究的加深,人們對AD的認識也會不斷加深,加之不斷累積的經驗,從根本上治愈AD的藥物必將在不久的將來研製成功。
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