[14] Gao Y,O'Caoimh R,Healy L,et al. Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia[J]. BMJ Open,2013,3(7): 2881.
[15] Hajjar I,Brown L,Mack WJ,et al. Impact of angiotensin receptor blockers on Alzheimer’s disease neuropathology in a large brain autopsy series[J]. Arch Neurol,2012,69(12):1632-1638.
[16] Katsouri L,Vizcaychipi MP,Mc Arthur S,et al. Prazosin,an α(1)-adrenoceptor antagonist,Prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease[J]. Neurobiol Aging,2013,34(4):1105-1115.
[17] Craft S,Baker LD,Montine TJ,et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment:A pilot clinical trial[J]. Arch Neurol,2012, 69(1):29-38.
[18] Hamano T,Yen SH,Gendron T,et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK[J]. Neurobiol Aging,2012,33(10):2306-2320.
[19] Wang Q,Zengin A,Ying W,et al. Chronic treatment with simvastatin up regulate smuscarinic M1/4 receptor binding in therat brain[J]. Neuroscience,2008,154 (3):1100-1106.
[20] Maurice W,Dysken,Mary Sano,et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease[J]. JAMA,2014,311(1):33-44.
[21] 趙緒韜,傅毅,董文心. β澱粉樣蛋白靶向藥物治療阿爾茨海默病的研究進展[J]. 世界臨床藥物,2013,34(1):49-54.
[22] Brunden KR,Trojanowski JQ,Lee VM. Advances in taufocuseddrug discovery for Alzheimer’s disease and relatedtauopathies[J]. Nat Rev Drug Discov,2009,8(10):783.
[23] Kurt R,Brunden,Bin Zhang,et al. Epothilone D improves microtubule density,axonal integrity,and cognition in a transgenic mouse model of tauopathy[J]. Neurosci,2010, 30(5):9-10.
[24] Farr SA,Erickson MA,Niehoff ML,et al. Central and peripheral administration of antisense oligonucleotide targeting amyloid-β protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (AβPPswe) mice[J]. Alzheimer's Dis,2014,40(4):1005-1016.
[25] Ze QQ,Yan Z,Yuan SZ,et al. Protective effects of a rhodiola crenulate extract and salidroside on hippocampal neurogenesis againststreptozotocin-induced neural injury in therat[J]. Plos One,2012,7(1):29641.
[26] 王秀琪,丁曉波,曾明. 川陳皮素對阿爾茨海默病的神經保護作用[J]. 重慶醫學,2014,43(22):2948-2951.
[27] Hou Y,Wang Y,Zhao J,et al. Smart soup,a traditional chinese medicine formula,Ameliorates amyloid pathology and related cognitive deficits[J]. Plos One,2014,9(11):e111215.
[28] Zhao Yongxin,Dou Jun,Wu Tao,et al. Investigating the antioxidant and acetylchol inesterase inhibition activities of gossypium herbaceam[J]. Molecules,2013,18(1):951-962.
[29] Xi Feifei,Feng Sang,Zhou Chunxiang,et al. Protective effects of Lingguizhugan decoction on amyloid-beta peptide(25-35)-induced cell injury anti-inflammatory effects[J]. Neural Regeneration Research,2012,36:2867-2873.
(收稿日期:2015-01-06)