（1）Theoretical guidance：
The research of the spatial evolution and development of polycentric regionmust consider the transaction cost factor under different system.Thestrategy designation of Yangtze River Delta-s development should focus on theprinciple of the combination of “microcosmic mechanism”and “macroscopicmechanism”.The research of “system，structure and performances”should betreated as a related integrity of the polycentric region to make the transactionefficiency become a core category of the regional development theory.
（2）Strategy comments：
To establish free，perfect regional markets as soon as possible；To improve the government-s macro‐control and guiding ability；To promote the unified planning and coordinated construction of the regionalinfrastructure network；To plan the distribution of urban system characterized by “concentration，dispersion and polycentricty”；To optimize the spatial distribution of the regional industry；To establish the regional development fund；To achieve the objective of the division of main‐functional zone；To improve the related policy， promote the sustained healthy developmentof the polycentric region.
Keywords：Polycentric Urban Region，spatial structure，coordinated development，Yangtze River Delta