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Study on preparation of matrine double-sensitive conlon-specofic
pellets and in vitro release
ZHANG Yong-gang， JIE Jing*
（Wuhan Bioengineering Institute， Wuhan 430415， China）
[Abstract] Objective： To prepare matrine double-sensitive conlon-specofic pellets and study the factors affecting its quality and evaluateing the colon-specific effects of preparation.Method： Matrine enzyme-sensitive pellets core were prepared by carboxymethyl konjac glucomannan as the main carrier material，and coated the core by acrylic resin Ⅱ and Ⅲ to prepare matrine double-sensitive conlon-specofic pellets. The prescription and technology of the matrine conlon-specofic pellets were studied by the single factor investigation ，through the in vitro release test and coating rate determination.Result： The optimized process conditions： FeCl3 concentration is 4. 0 g·L-1， chitosan concentration is 3.0 g·L-1， carboxymethyl konjac glucomannan concentration is 20 g·L-1， mixed gel solution pH value is 3. The release of matrine is less than 30% in the simulation of the upper gastrointestinal medium. The release of matrine is close to 100% in simulated full gastrointestinal medium，the coating weight is 7%.Conclusion： The prepared matrine pellets have good colon positioning effect in vitro.
[Key words] matrine； double-sensitive； colon-specific； pellets
doi：10.4268/cjcmm20140912