[6] 唐慧勤，馮旭，閻莉，等.亮葉楊桐總黃酮對高脂血症大鼠脂代謝的影響及其抗氧化作用[J].中成藥， 2013， 35（5）：899.
[7] Takashi O， Minoru Y， Shokei K， et al. Involvement of apeptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression [J]. Arterioscler Thromb Vasc Biol， 2004， 24（2）：270.
[8] 何薑，陳閔，劉小鶯，等.氧化應激對內皮細胞NF-κB、iNOS和NO信號表達的影響[J].福建醫科大學學報， 2010， 44（3）：186.
[9] Kevil C G， Oshima T， Alexander J S. The role of P38 MAP kinase in hydrogen peroxide mediated endothelial solute permeability [J]. Endothelium， 2001， 8（2）：107.
[10] 趙傑，官手濤，孫設宗，等.半枝蓮多糖清除氧自由基及抗脂質過氧化作用[J].中成藥， 2012， 34（7）：1361.
Effect of Antrodia cinnamomea on gene expression related to
aortal endothelial injury in rats with hyperlipidemia
QI Jie1， TAO Yun2， ZHANG Jun3*， FU Jian4
（1. College of Animal Science and Technology， Yangzhou University， Yangzhou 225009， China；
2. Olympic College， Nanjing Sport Institute， Nanjing 210000， China；
3. College of Physical Education， Shanghai Normal University， Shanghai 201400， China；
4. College of Physical Education， Yangzhou University， Yangzhou 225009， China）
[Abstract] Objective： To investigate the effect of Antrodia cinnamomea on gene expression related to aortal endothelial injury of rats with hyperlipidemia. Method： Fifty SD rats were randomly divided into five groups： the normal control group （NG）， the model group （MG）， the antrodia cinnamomea groups of low， middle and high doses （AC-LG， AC-MG， AC-HG， 250， 500， 1 000 mg·kg-1）. The rats were fed with high-fat diets to establish the hyperlipidemia model. After the drug administration for 10 weeks， their serum lipid， SOD， MDA and ox-LDL， LOX-1， P38MAPK and NF-κB mRNA and protein expression were respectively determined， and the aortal endothelial injury was observed under electron microscope. Result： In the model group， the contents of TC， TG and LDL-C significant increased（P
[Key words] Antrodia cinnamomea； SD rat； hyperlipimia； endothelial injury
doi：10.4268/cjcmm20140925