纈沙坦聯合硝苯地平緩釋片治療原發性高血壓的療效觀察
藥物與臨床
作者：林淑霞
[摘要] 目的 探討纈沙坦聯合硝苯地平緩釋片治療原發性高血壓的療效。 方法 選取64例原發性高血壓患者為研究對象，根據治療方法不同分為A、B兩組各32例。B組予硝苯地平緩釋片20 mg口服，1次/d，A組同時聯合口服纈沙坦40 mg，1次/d，連續治療4周。比較兩組用藥前、後4周患者的收縮壓（SBP）、舒張壓（DBP）的變化情況及兩組患者治療後的臨床療效。 結果 A組和B組治療前的SBP及DBP分別進行組間比較，差異無統計學意義（P>0.05）；治療後，A組SBP及DBP分別為（118.42±14.82）mm Hg和（80.47±6.23）mm Hg，分別顯著低於B組，組間比較，差異有統計學意義（P
[關鍵詞] 原發性高血壓；纈沙坦；硝苯地平緩釋片；不良反應
[中圖分類號] R544.1 [文獻標識碼] B [文章編號] 1673-9701（2015）08-0102-03
[Abstract] Objective To explore the effect of valsartan and nifedipine sustained-release tablets in treatment of essential hypertension. Methods A total of 64 cases of primary hypertension patients were selected as the research object， according to the different treatment methods they were divided into group A and group B， 32 cases in each group. Group B was treated with oral nifedipine sustained-release tablets 20 mg， 1 times/d， group A combined with oral valsartan 40 mg， 1 times/d， continuous treatment for 4 weeks. The changes of SBP，DBP and the clinical curative effect of two groups were compared before and after treatment. Results SBP and DBP in group A and group B before the treatment had no significant difference between two groups （P>0.05）； After the treatment，SBP and DBP of group A were （118.42±14.82）mm Hg and （80.47±6.23） mm Hg， were significantly lower than group B， the difference was statistically significant between two groups（P
[Key words] Hypertension； Stan； Nifedipine sustained-release tablets；Adverse reaction