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Effect of Taohong Siwu decoction on angiogenesis of medicine-induced
incomplete-abortion in early pregnancy rats and expressions of
Ang-1， Ang-2 and Tie-2
LIANG Jie， YIN Deng-ke， LI Bai-kun， LIU Zhu-qing， LI Shan-shan， CHEN Meng-xia， WANG Xiao-yu， PENG Dai-yin*
（School of Pharmacy， Anhui University of Chinese Medicine， Key Laboratory of Modern Traditional
Chinese Medicines of Anhui Province， Hefei ， China）
[Abstract] Objective： To observe the effect of Taohong Siwu decoction （THSWD） on micro-vascular density （MVD） in rat uterus， the content of angiopoietin-1 （Ang-1） and angiopoietin-2 （Ang-2） in serum， and the expression of tyrosine kinasa receptor （Tie-2） in uterus、 Method： Early pregnancy rats were intragastrically administrated with misoprostol （100 μg·kg-1） and mifepristong （8、3 mg·kg-1） to established the incomplete-abortion model、 The incomplete-abortion rats were randomly divided into the model group （the same volume of distilled water）， the positive control group （at the daily dose of 4、3 g·kg-1 Motherwort Particles）， and THSWD-treated groups （at the daily dose of 18、0， 9、0 and 4、5 g·kg-1）、 Pregnant rats were taken as the control group （the same volume of distilled water）、 After the successive oral administration for 7 days， blood was collected from aorta abdominalis， and rat uterine tissues were collected、 The content of serum Ang-1 and Ang-2 were detected by ELISA； And the levels of Tie-2 and MVD in uterine tissues were detected by SP immunohistochemistry、 Result： THSWD remarkably increased the levels of MVD in uterus of medicine-induced abortion rats， the content of Ang-1 and Ang-2 in serum， and the expression of Tie-2 in uterine tissues、 Conclusion： THSWD has the effect in markedly promoting angiogenesis in incomplete-abortion rats、 Its mechanism may be related to the regulation of concentrations of Ang-1 and Ang-2 in serum and Tie-2 in uterine tissues、
[Key words] Taohong Siwu decoction； MVD； Ang-1； Ang-2； Tie-2
doi：10.4268/cjcmm
[責任編輯張寧寧]