[4] Ha J M， Kang S Y， Park C W，et al. Effect of poloxamer on physicochemical properties of tacrolimus solid dispersion improving water solubility and dissolution rate[J]. J Pharm Invest，2012，42（4）： 171.
[5] 杜焰，趙立傑，熊耀坤，等.藥用粉體流動性的多元分析方法表征[J].藥學學報， 2012，47（9）： 1231.
[6] Zhou Q T，Armstrong B，Larson I，et al. Understanding the influence of powder flowability， fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders[J]. Eur J Pharm Sci，2010，40（5）：412.
[7] 鬱丹紅，劉丹，賈曉斌，等.基於生物藥劑學性質的中藥組分劑型的設計技術[J].中國實驗方劑學雜誌， 2012，37（19）： 2993.
[8] 李小妹，康誌英，梁詠，等.HPLC測定中風回春膠囊中丹酚酸B的含量[J].中國實驗方劑學雜誌， 2013，19（13）：122.
[9] Sun S P，Wei M，Olson J R，et al. Shaw biodegradable composites with aligned hydroxyapatite nanoneedles[J]. J Biomed Mater Res B，2012，100B（7）：1817.
[10] Pang X F， Zhou H W， Liu J L， et al. Investigation of biological property of nanohydroxyapatite materials [J]. J Nanosci Nanotechnol， 2012， 12（2）：894.
Studies on hydroxyapatite applicatied in coprecipitate of total
salvianolic acids phospholipid complex
CHEN Xiao-yun 2， ZHANG Zhen-hai LIU Dan SUN E JIA Xiao-bin 2*
（1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica， Jiangsu Provincial Academy of
Chinese Medicine， Nanjing 210028， China；
2. Nanjing University of Chinese Medicine， Nanjing 210046， China）
[Abstract] The purpose of this research was to prepare total salvianolic acids-phytosome-HA coprecipitate to improve drug dissolution and its micromeritic properties. Firstly， the coprecipitate was prepared by solvent method and in vitro dissolution of tripterine was performed with the salvianolic acid B and danshensu as criteria.At the same time， the micromeritic properties was characterizated， the structure of samples was characterized by TEM，DSC，XRD and FTIR.Results showed that when the ratio of drug to HA was 1∶2， it had a better dissolution， the accumulative drug-release percent in vitro at 60 min was over 90%. At the same time， it has good liquidityand low moisture absorption.Its micromeritic properties have improved. It is proved that the drug still existed amorphously by microstructure analysis. The preparation process is simple and feasible，it has practical value.
[Key words] total salvianolic acids phospholipid complex； hydroxyapatite； coprecipitate； micromeritic properties
doi：10.4268/cjcmm20140607