[5] McKenna D J， Jones K， Hughes K， et al. A survey of the geographic distribution of Ophiocordyceps sinens[J].Ther Health Med，2001，70：88.
[6] Paul F， Smith a， Karyn Maclennan a， et al. The neuroprotective properties of the Ginkgo biloba leaf： a review of the possible relationship to platelet-activating factor[J].J Ethnopharmacol， 1996，50：131.
[7] 劉丹，賈曉斌，蕭偉.質量分數權重係數法表征銀杏內酯組分溶解性及表觀油水分配係數的探討[J].中國中藥雜誌，2013，12（6）：1865.
[8] 張誌榮.藥劑學新技術及其在改善藥物功效中的作用[J].中國藥學雜誌，2009，44（20）：1525.
[9] 屠梅芳，施順清.試論中藥劑型改進的思路[J].中草藥，2001， 32（10）：956.
[10] Hiromasa Uchiyama， Yuichi Tozuka， Masaaki Imono，et al. Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with a-glucosyl hesperidin[J]. Int J Pharm， 2010，392：101.
[11] Furqan A Maulvia， Sonali J Dalwadib， Vaishali T Thakkarc， et al. Improvement of dissolution rate of aceclofenac by solid dispersion technique[J]. Powder Technol， 2011，207：47.
[12] Saquib H M， Nayak A K. Solubility and dissolution enhancement of ibuprofen by solid dispersions technology using PEG 6000-PVP K30 combination carrier[J]. Chemistry： Bulgarian J Sci Edu， 2012，21：118.
[13] 楊鵬飛，丁蘭萍，蔡曉蕾，等.銀杏內酯B自微乳的處方優選及質量、安全性評價[J]. 中國實驗方劑學雜誌，2013，19（12）：26.
Study on preparation of ginkgolides component solid dispersions
micro pill drug release unit
LIU Dan， ZHANG Zhen-hai， CHEN Xiao-yun， JIA Xiao-bin*
（Key Laboratory of New Drug Delivery System of Chinese Materia Medica，
Jiangsu Provincial Academy of Chinese Medicine， Nanjing 210028， China）
[Abstract] Microcrystalline cellulose and chitosan were applied to prepare ginkgolides component solid dispersions micro pill drug release unit and study the dissolution of GKS. Microcrystalline cellulose， chitosan as composite carrier， solvent method was used to prepare ginkgolides component solid dispersions. Differential scanning calorimetry was used to Characterization of ginkgolides component solid dispersions. Ginkgolides component solid dispersions as principle agent were prepared for micro-pellet. Comparison of different types， different doses of the adhesive， drug-polymer interactions， and disintegrating agent for the preparation of ginkgolides components of micro-pellet drug release unit， the optimum preparation ginkgolides components of micro-pellet drug release unit was screened by orthogonal design experiment. Preparation of ginkgolides components solid dispersions with microcrystalline cellulose and chitosan at ratio 1∶3. Drug cumulative dissolution was more than 80% in 60 min. Solid dispersion-micro-pellet drug release unit can significantly improve the dissolution of ginkgolides components， it has practical application value.
[Key words] ginkgolides components； micro-pellet； solid dispersions； drug release unit； dissolution
doi：10.4268/cjcmm20140609