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Study on decoction′s effect of different processed rhizomes of
Cibotium barometz on retinoic acid induced male rats osteoporosis
XU Gang 2， 3， SUN Na 2， 3， ZHAO Min-jie 2， 3， JU Cheng-guo 2， 3， JIA Tian-zhu 2， 3*
（1.School of Pharmacy Liaoning University of Traditional Chinese Medicine， Dalian 116600， China；
2.Chinese Materia Medica Processing Engineering Center of Liaoning Province， Dalian 116600， China；
3.The Key Laboratory of State Administration of Traditional Chinese Medicine， Dalian 116600， China）
[Abstract] This study compared the decoction′s HPLC figures of the different processed rhizomes of Cibotium barometz including the raw， the sand-baked， the wined， the steamed and the salted， on the basis of which， with the sand-baked Drynaria fortunei decoction as the positive control group， comparingall groups′decoction， concentration of which was 104.2 g·L-1， for 4 weeks， by their effects （s-TRAP and total scores of OPG， Ca， P， IL-6， TNF-α and IL-1） on retinoic acid induced male rats osteoporosis. The experiment results showed the sand-baked and the wined were better than the steamed， the salted and the raw；in the processing methods′ selection， the sand-baked was a better heating method than the steamed and the rice wine was the better excipient than the salt. It provided a reference to explain the processing principle of rhizomes of C. barometz and work mechanism of anti-osteoporosis.
[Key words] Cibotium barometz； processed products； decoction； retinoic acid； osteoporosis； osteoclast
doi：10.4268/cjcmm20140611