[8] Tennent G A， Hutchinson W L， Kahan M C， et al. Transgenic human CRP is not pro-atherogenic， pro-atherothrombotic or pro-inflammatory in apoE-/-mice[J]. Atherosclerosis， 2008， 196（1）： 248.
[9] Breitenstein A， Camici G G， Tanner F C. Tissue factor： beyond coagulation in the cardiovascular system[J]. Clin Sci （Lond），2009， 118（3）： 159.
[10] Kobayashi S， Okamoto K， Maesato K， et al. Important role of blood rheology in atherosclerosis of patients with hemodialysis[J]. Hemodial Int， 2005， 9（3）： 268.
Experimental study on pathogenetic evolvement regularity of phlegm， toxin and
blood-stasis syndromes in Chinese miniswine with phlegm-stasis cementation
syndrome of coronary heart disease
LIU Jian-xun*， LIN Cheng-ren， REN Jian-xun， LI Lei， REN Jun-guo， FU Jian-hua， LIU Guang-yu
（Institute of Basic Medical Sciences of Xiyuan Hospital， China Academy of Chinese Medical Sciences，
Beijing Key Laboratory of Chinese Materia Pharmacology， Beijing ， China）
[Abstract] Objective： To discuss that pathogenesis evolvement regularity of Chinese miniature swine with phlege-stasis cementation syndrome of coronary heart disease. Method： Eighteen Chinese miniature swine were randomly divided to the normal control group， the model group and the Danlou tablet group， with six swine in each group. Except for the normal control group， all of the other groups were fed with high fat diet for two weeks. The coronary heart disease model with phlegm-stasis cementation syndrome was established by injuring left anterior descending artery with interventional balloons and continuously feeding with high fat diet for eight weeks. The levels of BMI， hemorheological parameters， lipids in serum and inflammatory cytokines were observed at the 0th （before the experiment）， 2nd （before operation or drug administration）， 6th （four weeks after drug administration） and 10th week （eight weeks after drug administration） of study. The levels of TG and TC in liver and the pathological changes in coronary artery tissues were also observed at the end of study. Result： Compared with the normal control group， the model group had showed significant increase in the levels of TC， TG， LDL-C and VLDL-C in serum （P-1 and 60 s-1. At the 6th week， the levels of BMI and TG and TNF-α in serum significantly increased. At the 10th week， the levels of BMI and hs-CRP， IL-6 and TNF-α in serum significantly increased as well， with remarkable increase in coronary stenosis， intimal thickness and the ratio between intimal thickness and media thickness （P-1 and 60 s-1. Conclusion： The interaction of phlegm， blood stasis and toxin syndromes helps promote the progress and development of AS plaques， which is the key pathogenesis of phlegm-stasis cementation syndrome in coronary heart disease.
[Key words] coronary heart disease； Chinese miniature swine； phlegm-stasis cementation syndrome； toxin； pathogenesis regularity
doi：10.4268/cjcmm