[8] Nagarkatti N. Tumor derived Fas Ligand induces toxicity in lymphoid organs and plays an important role in successful chemotherapy[J]. Cancer Immunother，2000，49 （1）：46.
[9] 湯豔春，王吉波，孫雪輝，等.原發性幹燥綜合征唇腺組織中細胞凋亡及相關基因表達的研究[J].中華風濕病學雜誌，2004，8（9）：522.
[10] Saegusa K，Lshimarn N，Yanagi K，et al. Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome[J].J Immunol，2002，169（2）：1050.
Effect of nourishing Yin， strengthening Qi and activating blood decoction on
Fas/FasL in salivary glands of NOD mice with sjogren′s syndrome
and their mRNA expression
WU Guo-lin1， LI Tian-yi2*， LU Wen-wen1， YU Guo-you1， FAN Yong-sheng2
（1. First Affiliated Hospital， Medical College， Zhejiang University， Hangzhou ， China；
2. Zhejiang Chinese Medicine University， Hangzhou ， China）
[Abstract] Objective： To observe the effect of nourishing Yin， strengthening Qi and activating blood decoction on Fas/FasL in salivary glands of NOD mice with Sjogren′s syndrome and their mRNA expression. Method： Thirty-two NOD mice were randomly divided into the model group， the traditional Chinese medicine group （TCM group， orally given 0.4 mL nourishing Yin， strengthening Qi and activating blood decoction as per 100 g·kg-1 everyday）， the hydroxychloroquine group （given 0.4 mL hydroxychloroquine as per 60 mg·kg-1 everyday）， the traditional Chinese medicine and western medicine group （TCM WM group， given nourishing Yin， Strengthening Qi and activating blood decoction 50 g·kg-1and hydroxychloroquine 60 mg·kg-1， 0.4 mL everyday）， with eight mice in each group. Eight Balb/C mice were selected as the normal control group （normal group）. All of mice were killed after eight weeks， and their submaxillary glands were dissected. The expression levels of Fas/FasL were examined by immunohistochemical method， and the FasL mRNA was detected by RT-PCR. Result： The expression levels of Fas/FasL in salivary glands of the model group were higher than that of other groups （P
[Key words] sjogren′s syndrome； non-obese diabetic mouse； traditional Chinese medicine for nourishing Yin， strengthening Qi and activating blood； Fas/FasL
doi：10.4268/cjcmm