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Characteristic of urinary protein spectrum in patients with stage Ⅲ diabetic
nephropathy and its regression analysis with traditional
Chinese medicine symptom
WAN Yi-gang1， MENG Xian-jie2， SHEN Shan-mei1 *， LUO Xun-yang1， GU Liu-bao3， SHI Xi-miao2， YAO Jian4
（1.Nanjing Drum Tower Hospital， The Affiliated Hospital of Nanjing University Medical School， Nanjing ， China；
2.Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine， Nanjing University of
Chinese Medicine， Nanjng ， China；
3.Jiangsu Province Institute of Geriatrics， Nanjing ， China；
4. Department of Molecular Signaling University of Yamanashi， Yamanashi 409-3898， Japan）
[Abstract] To analyze the characteristic of urinary protein spectrum in patients with stage Ⅲ diabetic nephropathy（DN）and its compliance with traditional Chinese medicine（TCM）symptom， for the sake of providing a basis for clarifying the rules of TCM syndrome differentiation in DN. Adopting the traditional epidemiological retrospective method， thirty-eight TCM syndromes and urinary protein with medium or low molecular weight， as well as urinary enzyme， including 24 h urinary protein （Upro）， urinary albumin（UAlb）， urinary retinal binding protein（URBP）， urinary cystatin C（UCysC）， urinary N-acety1-β-D-glucosaminidase（UNAG）， were collected from 108 patients with stage Ⅲ DN， and a multiple factor regression analysis between them was conducted. As the results， the levels of Upro， UAlb， URBP， UCysC， and UNAG were increased in 108 patients with stage Ⅲ DN. Qi-Yin deficiency type was the major type. The level of UAlb in patients with Qi-Yin deficiency type was significantly higher than those without Qi-Yin deficiency type（P
[Key words] diabetic nephropathy； traditional Chinese medicine syndrome； urinary protein； regression analysis
doi：10.4268/cjcmm